After upgrading to Mac OS X 10.11.1, the PL2303 USB-serial driver didn’t work any more.

I used minicom for console connection. In my old configuration my device was /dev/tty.usbserial. After installing the driver from www.mac-usb-serial.com the changed to /dev/cu.Repleo-PL2303-00001014.

Find this with:

$ ls /dev/cu.*
/dev/cu.Bluetooth-Incoming-Port /dev/cu.Repleo-PL2303-00001014

Starting minicom -s you can easily follow the menu and change this.